Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1978-07-10
1980-10-14
Brown, Johnnie R.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 18, 536 22, 536 53, C07H 506, C07H 508
Patent
active
042282748
ABSTRACT:
The invention disclosed herein relates to novel 1-deoxy-glycopyranosides, preferably 1-deoxy-D-mannopyranosides, having in the 1-position of the pyranoside ring an .omega.-aminoalkylthio, .omega.-aminoalkyloxy or .omega.-aminoalkanoylamino substituent; and to novel processes for preparing these 1-substituted-1-deoxy-glycopyranosides starting with the corresponding tetra-O-acetyl-glycopyranosyl bromide or amine. These .omega.-amino(alkylthio, alkyloxy or alkanoylamino)-1-deoxy-glycopyranosides, and in particular 1-[(6'-aminohexyl)thio or oxy]-1-deoxy-D-mannopyranosides, possess insulin-like activity.
REFERENCES:
patent: 3243425 (1966-03-01), Whistler
patent: 3723617 (1973-03-01), Sutton
patent: 3939145 (1976-02-01), Gordon
patent: 3939146 (1976-02-01), Gordon
patent: 4017608 (1977-04-01), Gordon
Bugianesi Robert L.
Durette Philippe L.
Katzen Howard M.
Ponpipom Mitree M.
Shen Tsung-Ying
Brown Johnnie R.
Merck & Co. , Inc.
Rose David L.
Westlake Harry E.
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