1-substituted alkyl-2-oxo-hexahydroquinoxaline derivatives

Details 1-substituted alkyl-2-oxo-hexahydroquinoxaline derivatives 1-substituted alkyl-2-oxo-hexahydroquinoxaline derivatives

1988-10-19

1989-10-31

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D24144, C07D40306, C07D41306, A61K 31495

Patent

active

048778770

ABSTRACT:
1-Substituted alkyl-2-oxo-hexahydroquinoxaline derivatives of the formula ##STR1## wherein A is lower alkylene; R.sub.1 is selected from the group consisting of alkyl, phenyl-lower alkyl, and substituted phenyl-lower alkyl; and R is selected from the group consisting of hydroxyl, halogen, lower alkanocyloxy, R.sub.4 -carbamoyloxy and arylthio, in which R.sub.4 is lower alkyl or aryl; and pharmaceutically acceptable salts thereof. The compounds are useful as agents for platelet aggregation inhibition, vasodilation and anti-lipoperoxide generation.

REFERENCES:
patent: 4292240 (1981-09-01), Lai et al.
patent: 4296114 (1981-10-01), Appleton et al.
patent: 4837319 (1989-06-01), Yaso et al.

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