1-Substituted alkyl-2-oxo-hexahydroquinoxaline derivatives

Details 1-Substituted alkyl-2-oxo-hexahydroquinoxaline derivatives 1-Substituted alkyl-2-oxo-hexahydroquinoxaline derivatives

1988-10-19

1989-10-31

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544354, 540575, 540599, C07D40306, C07D40314, C07D40106, C07D41306

Patent

active

048778753

ABSTRACT:
1-Substituted alkyl-2-oxo-hexahydroquinoxaline derivatives of the formula ##STR1## wherein A is lower alkylene; R.sub.1 is selected from the group consisting of alkyl, phenyl-lower alkyl, and substituted phenyl-lower alkyl; and R is selected from the group consisting of 1-methyltetrazole-5-yl-thio, 1-imidazolyl, morpholino, ##STR2## in which R.sub.5 is hydrogen, lower alkyl or aryl, R.sub.6 is hydrogen, lower alkyl, hydroxy-lower alkyl, aryl, aryl-lower alkanoyl, arylcarbonyl, arylsulfonyl or thienyl-lower alkanoyl, Ar is phenyl or phenyl substituted with C.sub.1-3 alkyl, halogen, nitro, or lower alkoxy, A and R.sub.1 are as defined above, R.sub.2 and R.sub.3 are each lower alkyl or together form tetramethylene, m is an integer from 4-6, and n is 2 or 3; and pharmaceutically acceptable salts thereof. The compounds are useful as agents for platelet aggregation inhibition, vasodilation and anti-lipoperoxide generation.

REFERENCES:
patent: 3028384 (1962-04-01), Zellner et al.
patent: 4837319 (1989-06-01), Yaso et al.
Zellner et al., Chemical Abstracts, vol. 59, No. 11514 (1963).

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