1-Substituted alkyl-1,2-dihydro-2-pyrazinone derivatives

Details 1-Substituted alkyl-1,2-dihydro-2-pyrazinone derivatives 1-Substituted alkyl-1,2-dihydro-2-pyrazinone derivatives

1988-10-19

1989-09-26

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D24118, C07D40306, C07D24144, A61K 31495

Patent

active

048701769

ABSTRACT:
1-Substituted alkyl-1,2-dihydro-2-pyrazinone derivatives of the formula ##STR1## wherein A is lower alkylene; R.sub.1 is selected from the group consisting of alkyl, phenyl-lower alkyl, and substituted phenyl-lower alkyl; R.sub.2 and R.sub.3 are each lower alkyl; and R is selected from the group consisting of hydroxyl, halogen, lower alkanoyloxy, R.sub.4 -carbamoyloxy and arylthio, in which R.sub.4 is lower alkyl or aryl; and pharmaceutically acceptable salts thereof. The compounds are useful as agents for platelet aggregation inhibition, vasodilation and anti-lipoperoxide generation.

REFERENCES:
Mano, Chem Abs 94, 121843b (1980).

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