1-Substituted-4-pyrrolidinopiperidines as inhibitors of interleu

Details 1-Substituted-4-pyrrolidinopiperidines as inhibitors of interleu 1-Substituted-4-pyrrolidinopiperidines as inhibitors of interleu

1988-08-17

1990-02-20

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546193, 546159, 544356, 544283, 544336, 544322, C07D40102, A61K 31395

Patent

active

049028006

ABSTRACT:
There are disclosed compounds of the formula: ##STR1## wherein R is phenyl, naphthyl, pyridyl, quinolinyl, pyrazinyl, pyrimidinyl, quinoxalinyl quinazolinyl or any of the foregoing substituted with halo, lower alkyl, lower alkenyl, lower alkoxy, carboxy, lower alkoxycarbonyl, hydroxy, amino, mono- or diloweralkylamino, mercapto, lower alkylthio, lower alkylsulfonyl, cyano, nitro or trifluoromethyl; which, by virtue of their ability to inhibit interleukin 1, are of use as antiinflammatory agents and in treatment of disease states involving enzymatic tissue destruction.

REFERENCES:
patent: 3311624 (1967-03-01), Ohnacker et al.

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