1-Substituted-4-benzylpiperidines

Details 1-Substituted-4-benzylpiperidines 1-Substituted-4-benzylpiperidines

1976-01-27

1977-06-28

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

A61K 31445

Patent

active

040326420

ABSTRACT:
Novel 1-substituted-4-benzylpiperidines having .alpha.-substituents on the 4-benzyl moiety useful as anti-inflammatory agents, sedatives, and tranquilizers are represented by the formula ##STR1## wherein R represents acetyl, aryloxyloweralkyl, aroylloweralkylcarbamoyl, N-lower-alkylcarbamoyl, N,N-dilower-alkylcarbamoyl, N-arylcarbamoyl, N-(.omega.-nitrogen containing heterocycle)lower-alkylcarbamoyl, N(-.omega.-aminolower-alkyl)carbamoyl, 2-hydroxy-3-(o-methoxyphenoxy)propyloxycarbonyl, 2-carbamoylethyl, or 4-(p-fluorobenzoyl)piperidinoethyl; R.sup.1 represents hydrogen or hydroxy; R.sup.2 represents phenyl, p-fluorophenyl, m-trifluoromethylphenyl or cyclohexyl; Y represents hydrogen or fluorine with the proviso that when Y is hydrogen and R.sup.2 is phenyl, R is other than aroylloweralkyl. The pharmaceutically acceptable acid addition salts of the basic compounds of Formula I are included as part of the invention.

REFERENCES:
patent: 2739968 (1956-03-01), Sperber et al.
patent: 2739969 (1956-03-01), Sperber et al.
patent: 3000896 (1961-09-01), Hoffmann et al.
patent: 3073835 (1963-01-01), Rorig
patent: 3576810 (1971-04-01), Duncan et al.
patent: 3806526 (1974-04-01), Carr et al.

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