1-Substituted-4-(2-oxo-hexahydro-1-pyrimidinyl)-piperidine

Details 1-Substituted-4-(2-oxo-hexahydro-1-pyrimidinyl)-piperidine 1-Substituted-4-(2-oxo-hexahydro-1-pyrimidinyl)-piperidine

1976-01-28

1978-02-21

Daus, Donald G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602565R, 260268H, 260283S, 2602937, 26029369, 424251, A61K 31505, C07D40104

Patent

active

040752089

ABSTRACT:
Piperidines of the formula ##STR1## in which R.sub.1 stands for optionally substituted aryl, R.sub.2 for hydrogen, lower alkyl, lower alkenyl, acyl or .alpha.-aryl-lower alkyl, R.sub.3 for a free or substituted hydroxyl group, alk for lower alkylene which separates the two nitrogen atoms by 2 or 3 carbon atoms, R.sub.4 represents hydrogen or lower alkyl and n represents an integer from 1 to 4, and their salts as well as processes for their manufacture and pharmaceutical compositions comprising such compounds, and a process for lowering the blood pressure wherein such compositions are administered to a warm-blooded host.

REFERENCES:
patent: 3318900 (1967-05-01), Janssen
patent: 3459757 (1969-08-01), Wright et al.
patent: 3941789 (1976-03-01), Renth et al.

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