1-Substituted-4-(1,2-diphenylethyl)piperazine derivatives and co

Details 1-Substituted-4-(1,2-diphenylethyl)piperazine derivatives and co 1-Substituted-4-(1,2-diphenylethyl)piperazine derivatives and co

1976-03-02

1978-03-21

Gallagher, R.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

260268R, C07D29514, A61K 31495

Patent

active

040804534

ABSTRACT:
1-Substituted-4-(1,2-diphenylethyl)piperazine derivatives of the formula: ##STR1## wherein X is 2- or 3-hydroxy, 2-methoxy, 3-methyl, 3-alkoxy having 1 to 4 carbon atoms, or 2- or 3-alkanoyloxy having 2 to 5 carbon atoms; R is allyl, 3-hydroxyisoamyl, 3-methyl-2-butenyl, 3-methyl-3-butenyl, propyl, an unsubstituted monocycloalkyl having 5 to 8 carbon atoms, 2-chlorophenyl, or a phenyl substituted by hydroxy or methoxy; with proviso that when X is a substituent at position 2, R is cyclohexyl and when X is 3-methyl, R is 2-methoxyphenyl or an unsubstituted monocycloalkyl having 6 to 8 carbon atoms, and their pharmaceutically acceptable salts, and the preparation thereof, and analgesic or antitussive compositions containing the same as the essentially active ingredient.

REFERENCES:
patent: 3738986 (1973-06-01), Sandler et al.
Susumi Umemoto et al., Chemical Abstracts, vol. 77, 5521 (1972).
The Japanese Journal of Pharmacology, Apr. 27-29, 1972, p. 88.
Susumi Umemoto et al., Chemical Abstracts, vol. 78, 124634, (1973).
Susumi Umemoto et al., Chemical Abstracts, vol. 81, 37579, (1974).

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