1-Substituted-3-arylthio-4-hydroxypyrrolidines

Details 1-Substituted-3-arylthio-4-hydroxypyrrolidines 1-Substituted-3-arylthio-4-hydroxypyrrolidines

1979-01-09

1981-02-17

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fungus, except allergen, or component thereof or substance...

26032646, 26032647, 2603265S, 544105, C07D20712, A61K 3140

Patent

active

042515416

ABSTRACT:
Trans isomers of 1-substituted-3-arylthio-4-hydroxypyrrolidines and derivatives thereof having the formula: ##STR1## are disclosed wherein R.sub.1 is hydrogen, lower-alkyl, --C(O)NH-lower-alkyl and --C(O)-NH-phenyl; R.sub.2 is lower-alkyl, cycloalkyl and phenylalkyl; Ar is phenyl and substituted phenyl and the pharmaceutically acceptable addition salts thereof. The compounds have antidepressant activity in animals.

REFERENCES:
patent: 4160837 (1979-07-01), Paioni

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