1-substituted 3-aryl-7-chloro-3,4-dihydro(2H)-acridone N-oxides,

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514255, 514212, 514297, 540597, 544126, 544361, 546103, A61K 3147, C07D21906, C07D21908

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active

048032042

ABSTRACT:
The present invention relates to novel, 1-substituted 3-aryl-7-chloro-3,4-dihydro-(2H)-acridone N-oxides, a process for their preparation, pharmaceutical compositions containing these compounds, and their use as chemotherapeutic agents, in particular as antimalarials and coccidiostatics.

REFERENCES:
patent: 3947449 (1976-03-01), Durckheimer et al.
patent: 4260615 (1981-04-01), Raether et al.
patent: 4291034 (1981-09-01), Werbel
patent: 4593027 (1986-06-01), Winklemann et al.
Albert, "The Acridines", 2nd Ed., N.Y., St. Martin's Press (1966), pp. 376-377.
Winkelmann et al., Arzneim.-Forsch., vol. 37(6), pp. 647-661 (6/87).
Winkelmann et al., Chemical Abstracts, vol. 107:108835t (1987).
Durckheimer et al., Arzneimittelforschung, Drug Research 30(11), No. 7, pp. 1041-1046 (1980).
Werbel et al., Eur. J. Med. Chem., Chim. Ther. 20, No. 4, pp. 363-370 (1985).

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