1-Substituted-2-(2-pyridinyl)ethanone N-oxides

Details 1-Substituted-2-(2-pyridinyl)ethanone N-oxides 1-Substituted-2-(2-pyridinyl)ethanone N-oxides

1975-09-08

1977-11-01

Jaisle, Cecilia M. S.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

260295AM, 260295R, 260296D, 260296R, 260297R, 260473R, 544 94, 544 92, 542453, 560 61, 560 62, C07D21389, A61K 3144

Patent

active

040566196

ABSTRACT:
1-Substituted-2-(2-pyridinyl)ethanone N-oxides having the formula I or II: ##STR1## wherein R.sub.1 is hydrogen or lower alkyl; R.sub.2 and R.sub.3 are each hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, or benzyloxy; R.sub.4 is halogen, hydroxy, lower alkyl, lower alkoxy, benzyloxy, ortho-amino, ortho-lower alkylamino, ortho-alkanoylamino or ortho-benzoylamino; and R.sub.5 is hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy or benzyloxy; the pharmaceutically acceptable acid addition salts thereof, and a process for the preparation thereof, are described. The compounds of this invention are useful for the treatment of allergic conditions and for the treatment of hyperacidity.

REFERENCES:
patent: 3980657 (1976-09-01), Haas et al.
Osborne, et al., J. Het. Chem. vol. I (July, 1964) pp. 138-140.
Theilheimer, Syn. Meth. of Org. Chem., vol. II, p. 9, #32 (Interscience, N. Y. 1949).

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