Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1983-04-29
1985-01-22
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546321, 546194, 546268, 546281, 546283, 546284, 514929, 514336, 514356, A61K 31455, C07D21194, C07D40112, C07D40512
Patent
active
044951922
ABSTRACT:
A vasodilating or anti-hypertensive composition comprises a pharmaceutical carrier and an effective amount of a 1,4-dihydropyridine compound as an active ingredient. The 1,4-dihydropyridine compound may be represented by the following general formula: ##STR1## wherein R'.sub.1 and R'.sub.4 represent a hydrogen atom, R'.sub.2 and R'.sub.3 represent an alkyl group having 1-5 carbon atoms or a substituted heterocyclic group wherein a substituent is an N-benzylpiperidyl group, R'.sub.5 represents a nitro group, and R'.sub.6 and R'.sub.7 represent an alkyl group having 1-5 carbon atoms.
REFERENCES:
patent: 3966948 (1976-06-01), Bossert et al.
patent: 4145432 (1979-03-01), Sato
patent: 4393070 (1983-07-01), Sato et al.
Kurbatova, et al., "Chemistry of Heterocyclic N-Oxides and Related Compounds", Chem. Abstracts 91:91466z.
Hashimoto Tamotsu
Hatta Takao
Muto Kenji
Takemoto Yoshinori
Watanabe Minoru
Bjorkman Dale A.
Kyowa Hakko Kogyo Co. Ltd.
Rotman Alan L.
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