1-Substituted-1,2-dihydrothieno[2,3-d]-pyrimidin-2-one derivativ

Details 1-Substituted-1,2-dihydrothieno[2,3-d]-pyrimidin-2-one derivativ 1-Substituted-1,2-dihydrothieno[2,3-d]-pyrimidin-2-one derivativ

1975-05-06

1977-01-04

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

260251A, 2602564F, 2602565R, 2602472A, 2602477R, 2602477V, 2602477Z, 26029357, 2603323R, 2603305, 260329AM, 2603322R, C07D49504, A61K 31495

Patent

active

040014126

ABSTRACT:
1-Substituted-1,2-dihydrothieno[2,3-d]-pyrimidin-2-ones of the formula, ##STR1## wherein R is lower alkyl or cyclopropylmethyl, R.sub.1 is halogen, lower alkyl or nitro, R.sub.2 is hydrogen or lower alkyl and R.sub.3 is hydrogen or halogen, are obtained by treating a trihaloacetamidothiophene derivative with ammonia. These compounds have excellent pharmacological activities such as uricosuric activity.

REFERENCES:
patent: 3830813 (1974-08-01), Woitum et al.
Robba et al., Chemical Abstracts v. 70, 37,767b (1969).
Robba et al., Chemical Abstracts, v. 69, 27,365; (1968).
Robba et al., Chemical Abstracts, v. 69, 96,635, (1968).
Sauter, Chemical Abstracts, v. 69, 96,647q (1968).
Gronowitz et al., Chemical Abstracts, v. 70, 87,745p (1969).
Manhas et al., Chemical Abstracts, v. 71, 101,801h (1969).
Schweizer et al., Chemical Abstracts, v. 72, 90,498g (1970).
Manhas et al., Chemical Abstracts, v. 76, 107,846b (5/8/72).

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