1'S, 5R, 6R-carbapenem derivatives and antimicrobial agents comp

Details 1'S, 5R, 6R-carbapenem derivatives and antimicrobial agents comp 1'S, 5R, 6R-carbapenem derivatives and antimicrobial agents comp

1997-08-15

2000-04-18

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540350, A61K 3140, C07D47720

Patent

active

060515694

ABSTRACT:
A carbapenem derivative represented by the following formula (I), ##STR1## wherein R.sub.1 represents a hydrogen atom, a substituted or unsubstituted aryl group, or a substituted or unsubstituted heterocyclic group, R.sub.2 indicates a hydrogen atom or a protective group for a carboxyl group, and R.sub.3 is a methyl group or an ethyl group; or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising this carbapenem derivative or a salt thereof as an active ingredient. The carbapenem derivative exhibits a wide and strong antimicrobial activity, particularly a strong antimicrobial activity against MRSA. An intermediate compound for preparing the carbapenem derivative is also disclosed.

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Yoshihiro Sumita, et al.: "Antimicrobial Activity of SM-17466, a Novel Carbapenem Antibiotic with Potent Activity against Methicillin-Resistant Staphylococcus aureus", Antinmicrobial Agents and Chemotherapy, vol. 39, No. 4, Apr. 1994, pp. 910-916.
Database WPI; Section Ch, Week 9617; Derwent Publications Ltd., London, GB; Class B02, AN 96-171546; XP002049266 (1996).

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