(1'R,3S,4R)4-acylthio azetidinones

Details (1'R,3S,4R)4-acylthio azetidinones (1'R,3S,4R)4-acylthio azetidinones

1993-04-30

1995-03-21

Rizzo, Nicholas

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540358, C07D49900, A61K 31425

Patent

active

053996798

ABSTRACT:
There is provided a process for preparing a compound of formula (I) ##STR1## wherein R is H or a hydroxy protecting group, R.sub.2 is an organic residue and R.sub.3 is H or a nitrogen protecting group, which process comprises reacting together a compound of formula (II) ##STR2## wherein R.sub.1 is a C.sub.1 -C.sub.4 alkyl or a phenyl group, R and R.sub.3 are as defined above, a compound of formula (III) ##STR3## wherein R.sub.2 is as defined above and X is a cation or a silicon-containing residue, and a salt of a group IIa, IIb or transition element. The compounds of formula (I) are intermediates in the synthesis of penem antibiotics.

REFERENCES:
patent: 4631150 (1986-12-01), Battistini et al.
patent: 4782145 (1988-11-01), Brighty
patent: 4952577 (1990-08-01), Alpegiani et al.
patent: 4962196 (1990-10-01), Hungerbuhler et al.
Tetrahedron Letters, vol. 35, No. 20, pp. 3379-3382, 1994.

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