1-Pyrimidinyloxy-3-hetaryl-alkylamino-2-propanols

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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544319, 544320, 544321, 514397, 514398, C07D23947, A61K 31505

Patent

active

045171882

ABSTRACT:
1-(4-Pyrimidinyloxy)-3-(hetarylalkylamino)-2-propanols are cardiovascular agents having a range of vasodilator and adrenergic beta-receptor blocking activities making these compounds useful anti-hypertensive agents. Preferred compounds bear a hydrazino or hydrazono substituent in the 2- position of the pyrimidine ring.

REFERENCES:
patent: 3337628 (1967-08-01), Crouther
patent: 4042586 (1977-08-01), Wasson
patent: 4139623 (1979-02-01), Jaeggi
patent: 4193995 (1980-03-01), Wasson
patent: 4321398 (1982-03-01), Matier
patent: 4324788 (1982-04-01), Dorigotti
Antonio et al., J. Med. Chemistry, 21, 123.

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