1-pyrimidinylacetamide compounds which are inhibitors of human l

Details 1-pyrimidinylacetamide compounds which are inhibitors of human l 1-pyrimidinylacetamide compounds which are inhibitors of human l

1995-01-19

1998-04-07

Bernhardt, Emily

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Boron containing doai

544 69, 544229, A61K 3169, C07F 502, C07F 504

Patent

active

057365350

ABSTRACT:
The present invention relates to certain novel substituted derivatives which are 1-pyrimidinylacetamide derivatives of formula I, ##STR1## which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these substituted derivatives, processes for preparing the substituted derivatives, pharmaceutical compositions containing such substituted derivatives and methods for their use.

REFERENCES:
patent: 4499082 (1985-02-01), Shenvi et al.
patent: 4537773 (1985-08-01), Shenvi
patent: 4910190 (1990-03-01), Bergerson et al.
patent: 4963655 (1990-10-01), Kinder et al.
patent: 5169841 (1992-12-01), Kleeman et al.
patent: 5254558 (1993-10-01), Bernstein et al.
Drug Evaluations by American Medical Association pp. 509-510 (1993).

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