1-(pyridinylalkyl)-1H-indoles, indolines and related analogs

Details 1-(pyridinylalkyl)-1H-indoles, indolines and related analogs 1-(pyridinylalkyl)-1H-indoles, indolines and related analogs

1991-06-27

1993-05-25

Fan, Jane T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546273, C07D40106, A61K 3144

Patent

active

052140580

ABSTRACT:
This invention relates to compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, loweralkyl, arylloweralkyl, loweralkenyl or loweralkynyl;

REFERENCES:
patent: 4880822 (1989-11-01), Effland et al.
CA: 109:150001j--Tet. Letters, 1987-28(48), pp. 6077-6080.
J. Bosch et al., Mercuric Acetate Cyclization of 4-(Pyrrolymethyl and 4-(Indolymethyl)piperidines to Bridged Polycyclic Systems, J. Org. Chem. 48, 25 (1983) 4836-41.
C. W. Whitehead et al., Effect of Lipophilic Substituents on Some Biological Properties of Indoles, J. Med. Chem. 17, 12 (1974), 129 1304.
Bosch et al., Synthetic Studies on the Indole Alkaloid Vinoxine, 51, 12, (1986), 2289-97.
J. Bosch et al., Model Studies in the Vinoxine Series, Heterocycles, 19, 5 (1982), 853-56.
M. L. Bennasar et al., Synthetic Applications of 2-Cyanopiperidines, Tetrahedron, 42, 2 (1986), 637-47.
CA 70:19857b Sheinkman et al.

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