1-piperazinyl-2-butenes and -2-butynes

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514252, 514254, 544230, 544295, 544362, 544363, 544364, 544368, 544369, 544376, A61K 31495, A61K 31445, C07D41706, C07D41714

Patent

active

051944367

ABSTRACT:
Novel 1-piperazinyl-2-butenes and -2-butynes, intermediates and processes for the preparation thereof, and methods of treating psychoses utilizing compounds or compositions thereof are disclosed.

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Y. Kojima, et al., Chemical Abstracts, vol. 110, p. 557, abstract 23914e (1989), entitled "Preparation of N-(piperazinylbutyl)imide Derivatives as Tranquilizers and Psychotropics".
J. P. Yevich, et al., Journal of Medicinal Chemistry, vol. 26, pp. 194 to 203 (Feb., 1983), entitled "Buspirone Analogues". 1. Structure-Activity Relationships in a Series of N-ARyl- and Heteroarypiperazine Derivatives.
Y. -H. Wu, et al., Journal of Medicinal Chemistry, 12, 876 (1969).
M. S. Gibson and R. W. Bradshaw, Angewandte Chemie, International Edition, 7, 919 (1968).

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