Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Patent
1993-02-01
1994-08-02
Tsang, Cecilia
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
544230, 544295, 544362, 544363, 544364, 544368, 544369, 544373, 544376, 544 54, C07D29500, C07D40300, C07D41300, C07D40100
Patent
active
053347153
ABSTRACT:
Novel 1-piperazinyl-2-butenes and -2-butynes, intermediates and processes for the preparation thereof, and methods of treating psychoses utilizing compounds or compositions thereof are disclosed.
REFERENCES:
patent: 4367335 (1983-01-01), Temple et al.
patent: 4933453 (1990-06-01), Hrib et al.
patent: 5034392 (1991-07-01), Hrib
Y.-H. Wu, et al., Journal of Medicinal Chemistry, 12, 876 (1969) published in the U.S. and entitled "Psychosedative Agent, N-(4-Phenyl-1-piperazinylalkyl)-Substituted Cyclic Amides".
M. S. Gibson and R. W. Bradshaw, Angewandte Chemie, International Edition 7, 919 (1968) published in the U.S. and entitled "The Gabriel Synthesis of Primary Amines".
Y. Kojima, et al., Chemical Abstracts, vol. 110, p. 557, abstract 23914e (1989), published in the U.S. and entitled "Preparation of N-(piperazinylbutyl)imide Derivatives as Tranquilizers and Psychotropics".
J. P. Yevich, et al., Journal of Medicinal Chemistry, vol. 26, pp. 194 to 203 (Feb. 1983), published in the U.S. and entitled "Buspirone Analogues. 1. Structure-Activity Relationships in a Series of N-Aryl- and Heteroarypiperazine Derivatives".
German Offenlegungsschrift DE 36 20 643, published Jan. 22, 1987 and English translation thereof.
Hrib Nicholas J.
Jurcak John G.
Ong Helen H.
Perez Joseph
Hoechst-Roussel Pharmaceuticals Inc.
Tsang Cecilia
Wittekind Raymond R.
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