1-Phenylthiopropyl-4-hydroxy-4-phenyl piperidines

Details 1-Phenylthiopropyl-4-hydroxy-4-phenyl piperidines 1-Phenylthiopropyl-4-hydroxy-4-phenyl piperidines

1974-06-21

1976-06-01

Winters, Sherman D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D21152

Patent

active

039608735

ABSTRACT:
Novel N-substituted heterocyclic derivatives represented by the formula, ##SPC1##
Wherein R.sub.1 is hydrogen atom, lower alkyl, lower alkoxy, nitro, halogen or trifluoromethyl group; R.sub.2 is hydrogen atom or lower alkyl group; X is sulfur atom, sulfinyl or sulfonyl group; Y is ##EQU1## group (wherein R.sub.3 is phenyl or substituted phenyl group; R.sub.4 is hydrogen atom, hydroxy, lower alkyl, lower alkoxy, lower alkanoyl, lower alkanoyloxy, carbamoyl, N-(lower alkyl)-carbamoyl or N,N-di(lower akyl)-carbamoyl group; R.sub.5 is hydrogen atom, morpholino, pyrrolidinyl, piperidinyl, hexamethylenimino, lower alkyl, cyclo(lower alkyl), cyclo(lower alkyl)-(lower alkyl), hydroxy-(lower alkyl), (lower alkoxy)-(lower alkyl), phenyl or substituted phenyl group; k is 0 or 1 and m is 0, 1 or 2); and n is 3 or 4, and pharmaceutically acceptable salts thereof, which have excellent tranquillizing, anti-psychotonic, anti-emotional, anti-convulsive, anti-psychosis, sedative, analgesic or anti-hypertensive activities.

REFERENCES:
patent: 2846437 (1958-08-01), Elpern
patent: 2850500 (1958-09-01), Elpern
patent: 3052683 (1962-09-01), Carabateas
patent: 3356657 (1967-12-01), Walker
patent: 3674799 (1972-07-01), Edenhofer et al.
Porszasz et al., Arzneimittel-Forsch, 14: 1343-1349 (1964).
Wasserman et al., C.A. 57: 12428h (1962).

Affiliated with

Also associated with

Rating

1-Phenylthiopropyl-4-hydroxy-4-phenyl piperidines does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 1-Phenylthiopropyl-4-hydroxy-4-phenyl piperidines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1-Phenylthiopropyl-4-hydroxy-4-phenyl piperidines will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2402604