1-Phenylpiperazines

Details 1-Phenylpiperazines 1-Phenylpiperazines

1979-07-27

1981-05-12

Sutto, Anton H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544392, 424250, C07D29506, A01N 4360

Patent

active

042673283

ABSTRACT:
Phenylpiperazine derivatives having the general formula (I) ##STR1## in which R.sub.1 represents a radical S(O).sub.m R.sub.3, S(O).sub.n CF.sub.3 or ##STR2## in which radicals m is 0, 1 or 2, n is 1 or 2, R.sub.3 is an alkyl radical having 1 to 10 carbon atoms and R.sub.4 and R.sub.5 independently represent a hydrogen atom or an alkyl radical having 1 to 4 carbon atoms, or the N atom, R.sub.4 and R.sub.5 together form a heterocyclic ring, which can contain another hetero-atom, and R.sub.2 represents a hydrogen atom, the radical CH.sub.2 --CH.sub.2 --OH or a radical of formula CH.sub.2 --CH.sub.2 --O--COR.sub.6, CH.sub.2 --CH.sub.2 --O--CONHR.sub.6 or CH.sub.2 --CH.sub.2 --O--R.sub.6 in which radicals R.sub.6 being an alkyl radical having 1 to 6 carbon atoms and their pharmaceutically acceptable acid addition salts are useful psychotropic agents and analgesics. Compounds in which R.sub.1 is --SCH.sub.3 and simultaneously R.sub.2 is H are not part of the invention. These derivatives can be prepared by reacting an aniline derivative of formula ##STR3## with a compound of formula ##STR4## in which X represents a halogen atom or OH, alkyl--SO.sub.3 or aryl--SO.sub.3 group or the two X symbols together represent a divalent oxygen atom, thereby completing a morpholine ring.

REFERENCES:
patent: 2836594 (1958-05-01), Parcell
patent: 3007928 (1961-11-01), Parcell
patent: 3028390 (1962-04-01), Parcell
patent: 3170926 (1965-02-01), Ash et al.
patent: 3929792 (1975-12-01), Bouchara
patent: 3954763 (1976-05-01), Giudicelli et al.

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