1-phenylmethyl benzimidazole piperazine derivative

Details 1-phenylmethyl benzimidazole piperazine derivative 1-phenylmethyl benzimidazole piperazine derivative

1996-01-22

1997-09-30

Bernhardt, Emily

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544370, A61K 31495, C07D40304

Patent

active

056726040

ABSTRACT:
New 1-phenylmethyl enzimidazole piperazine derivatives of general formula ##STR1## are described wherein R.sup.1 and R.sup.2 can be a hydrogen atom, a halogen atom, a short chain alkyl group, a nitro group, and a hydroxy group, and their addition salts with pharmaceutically acceptable acids.
These compounds have pharmacological activity as serotonin 5HT.sub.3 receptor antagonists.

REFERENCES:
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patent: 5256665 (1993-10-01), Orjales-Venero et al.
Iemura et al, Chem. Pharm. Bull, 37(10), pp. 2723-2726 (1989).
Iemura et al, Chem. Pharm. Bull. 37 (4) pp. 967-972 (1989).
Kodama et al., Chemical Abstracts, vol.84, No.44060 (1976) (Abs. for JP 126682, Oct. 4, 1975).
Hasegawa et al., Chemical Abstracts, vol.82, No.156308 (19).

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