1-Phenylindazole-3-one compounds, process and intermediates for

Details 1-Phenylindazole-3-one compounds, process and intermediates for 1-Phenylindazole-3-one compounds, process and intermediates for

1982-08-19

1984-05-15

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544364, 544371, 548372, C07D40306, C07D48700, C07D23156, A61K 31495

Patent

active

044487770

ABSTRACT:
New 1-phenylindazol-3-one compounds are described which have the formula I ##STR1## where R.sub.1 is a hydrogen or halogen atom, or a lower alkyl, lower alkoxy or trifluoromethyl radical, R.sub.2 is a hydrogen or halogen atom, or a lower alkyl or lower alkoxy radical, R.sub.3 is a hydrogen or halogen atom, or a lower alkyl, lower alkoxy or trifluoromethyl radical, R.sub.4 is a hydrogen or halogen, atom, or a lower alkyl or lower alkoxy radical, Z is an alkylene radical with 2 to 6 carbon atoms and R.sub.5 is an unsubstituted or substituted pyridyl radical, a thienyl radical or an unsubstituted or substituted phenyl radical. The compounds have pharmacological actions, for example antiallergic actions. Methods of preparing these compounds are described as well as intermediates useful in these methods. Pharmaceutical compositions containing the compounds are also described.

REFERENCES:
patent: 3423413 (1969-01-01), Priewe et al.
patent: 3736332 (1973-05-01), Butula
patent: 3994890 (1976-11-01), Fujimura et al.
Schmutz, J. et al., Helv. Chim. Acta, 47, 1986-1996, (1964).
L. Baiocchi et al., "Synthesis, Properties and Reactions of 1H-Indazol-3-ols and 1,2-Dihydro-3H-Indazol-3-ones", Synthesis, Sep. 1978, pp. 633-648, European Search Report.

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