1-Phenyl-lower alkyl-imidazole 4- or 5-carboxamide compounds whi

Details 1-Phenyl-lower alkyl-imidazole 4- or 5-carboxamide compounds whi 1-Phenyl-lower alkyl-imidazole 4- or 5-carboxamide compounds whi

1987-05-26

1989-07-25

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548343, C07D23370, A61K 31415

Patent

active

048514241

ABSTRACT:
1-Phenyl-lower alkylimidazole-4- and/or 5-carboxamides of the formula ##STR1## in which Ph represents phenyl substituted by lower alkyl and/or by halogen, alk represents lower alkylidene, one of the radicals R.sub.1 and R.sub.2 is carbamoyl optionally substituted by lower alkyl or by lower alkanoyl and the other is hydrogen, lower alkyl, or carbamoyl optionally substituted by lower alkyl or by lower alkanoyl, and R.sub.3 represents hydrogen or lower alkyl, have anticonvulsive properties and can be used as anticonvulsives. They are manufactured as follows: in a compound of the formula ##STR2## in which R.sub.1 ' represents a radical R.sub.1 or X and R.sub.2 ' represents a radical X, or R.sub.1 ' represents a radical X and R.sub.2 ' represents a radical R.sub.2, where X represents a group that can be converted into carbamoyl that optionally is mono- or di-substituted by lower alkyl or monosubstituted by lower alkanoyl, the radical X or the radicals X is/are converted into carbamoyl that optionally is mono- or di-substituted by lower alkyl or monosubstituted by lower alkanoyl.

REFERENCES:
patent: 2897205 (1959-07-01), Leanza
patent: 3691178 (1972-09-01), Baldwin et al.
patent: 3991072 (1976-11-01), Roevens et al.
patent: 4185992 (1980-01-01), Gilnour
patent: 4346097 (1982-08-01), Schweiss et al.
Derwent Abstr. 84-272807/44 of Japanese 84/167515A, (9/84).
CA 102:56152t (1985).
CA 94:30642u (1981).
Derwent Abstract 72139x/39 of Belgium 839120 (9/76).

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