1-phenyl-6-one-pyrimidine derivatives

Details 1-phenyl-6-one-pyrimidine derivatives 1-phenyl-6-one-pyrimidine derivatives

1990-04-09

1992-04-14

Ford, John M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514272, 514274, 544299, 544301, 544302, 544303, 544309, 544311, 544312, 544313, 544314, 544319, 544321, C07D23936, C07D23938, A01N 4354

Patent

active

051048787

ABSTRACT:
A compound of formula (I): ##STR1## wherein R.sup.1 and R.sup.2 are independently selected from hydrogen, halogen, haloalkyl, alkoxy or nitro, provided that R.sup.1 and R.sup.2 are not both nitro; R.sup.3 and R.sup.4 are independently selected from hydrogen, halogen, alkyl or cycloalkyl; R.sup.5 is halogen, nitro, haloalkyl, haloalkoxy or --S(O).sub.n R.sup.10 ; R.sup.6 is halogen, nitro, haloalkyl, haloalkoxy or --S(O).sub.n R.sup.10 ; R.sup.7 is hydrogen, halogen, hydroxyalkyl, cyano, nitro, alkoxy, --S(O).sub.n R.sup.10, NR.sup.11 R.sup.12, haloalkyl or formyl; R.sup.8 is hydrogen, halogen, NR.sup.11 R.sup.12, alkyl, cycloalkyl or S(O).sub.n R.sup.10 ; and R.sup.9 is oxygen or sulphur; where n is 0, 1 or 2; and R.sup.10 is alkyl, haloalkyl or cycloalkyl; and R.sup.11 and R.sup.12 are independently selected from hydrogen, alkyl or cycloalkyl or R.sup.11 and R.sup.12 together with the nitrogen to which they are attached form a heterocyclic group; provided that when R.sup.5 is trifluoromethyl at least one of the following applies:

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patent: 4145546 (1979-03-01), Brown et al.
patent: 4147528 (1979-04-01), McNulty et al.
Chemical Abstracts, vol. 105, No. 23, Dec. 8, 1986, p. 566, Abstract No. 208595s, Columbia, Ohio, U.S.; & JP-A-61 083 146 (Nippon Soda Co., Ltd.), Apr. 26, 1986.

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