Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Patent
1997-01-30
1999-01-12
Bernhardt, Emily
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
514255, C07D295073, C07D295076, C07D295027, A61K 31495
Patent
active
058592466
ABSTRACT:
Disclosed are compounds of the formula: ##STR1## or the pharmaceutically acceptable addition salts thereof wherein: R.sub.1 is halogen or C.sub.1 -C.sub.4 alkyl; and
REFERENCES:
patent: 2830056 (1958-04-01), Ruschig et al.
patent: 3845058 (1974-10-01), Lembo et al
patent: 4370329 (1983-01-01), Scherm et al.
patent: 4370330 (1983-01-01), Scherm et al.
patent: 5607946 (1997-03-01), Kulagowski et al.
patent: 5681954 (1997-10-01), Yamamoto et al.
R.B. Petigara, et al., "Synthesis and Central Nervous System Depressant Activity of New Piperazine Derivatives," J. Med. Chem., 11: 196, 8 pp. 332-336 (1968).
Reitz et al., J. Med. Chem. 37(8) pp. 1060-1062 (1994).
Prasad et al, J. Med. Chem, 11, pp. 1144-1150 (1968).
Drug Evaluations by American Medical Association p. 380 (1993).
Morren et al, Chemical Abstracts, vol. 59, No. 8732b (1963).
Mokrosz et al, J. Med. Chem, 35, pp. 2369-2374 (1992).
Van Tol, H. H. et al., "Cloning of the gene for a human dopamine D.sub.4 receptor with high affinity for the antipsychotic clozapine," Nature, 350, 610-614 (Apr. 18, 1991). PET Radiotracer Synthesis: Model Alkylation Studies and Its Application in the Design of Dopamine D.sub.1 and D.sub.2 Receptor-based Imaging Agents," Nucl. Med. Biol., 20(6), 777-794 (1993).
Chen Xi
Thurkauf Andrew
Bernhardt Emily
Neurogen Corporation
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