1-phenyl-3-aryl-2-propyne-1-one useful as calcium uptake inhibit

Details 1-phenyl-3-aryl-2-propyne-1-one useful as calcium uptake inhibit 1-phenyl-3-aryl-2-propyne-1-one useful as calcium uptake inhibit

1992-06-01

1993-06-29

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514351, 514357, 546300, 546301, 546302, 546312, 546334, 546340, A61K 3144, C07D21346, C07D21373, C07D21374

Patent

active

052235181

ABSTRACT:
This invention relates to 1-phenyl-3-aryl-2-propyne-1-ones, the use of these compounds as calcium uptake inhibitors in leukocytes and thrombocytes, and pharmaceutical compositions containing these compounds as active ingredients, and the process of their preparation.

REFERENCES:
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patent: 4929741 (1990-05-01), Fischli et al.
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Jong, T. T., et al., Chem. Soc., Perkin Trans. 1(2), 423-4 (1990); Chem. Abst. 113,97350b.
Chen, F., et al., Tai-Wan K'o Hsueh 26(3-4), 98-9 (1972); Chem. Abst., 78(23), 147754t, Jun. 11, 1979.
Durinda, J., et al., Cesk. Farm. 26(5), 140-9 (1977); Chem. Abst. 88(1), 6671h, Jan. 2, 1978.
Boedeker, J., et al., J. Prakt. Chem. 324(1), 15-20 (1982); Chem. Abst. 97(3), 23594p, Jul. 19, 1982.
Sacchar, S. P., et al., Bokin Bobai 11(5), 269-74 (1983); Chem. Abst. 99(7), 139709A, Oct. 24, 1983.
Minn, K., 8th Int. Conf. on Organic Synthesis (IUPAC), Helsinki, 23-27 Jul. 1990.

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