1-Phenyl-2-aminoethanol derivatives

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

260239A, 2603264, 546226, 424274, C07D20504, C07D20716, C07D21160, C07D21162, A61K 31395, A61K 3140, A61K 31445

Patent

active

043235751

ABSTRACT:
The invention concerns compounds of the formula:- R.sup.1.CH(OH).CH.sub.2 NH.CR.sup.2 R.sup.3.A.sup.1. NH.CO.CHR.sup.4.A.sup.2.NR.sup.5. Q I wherein R.sup.1 is 3,4-bis[(3-8C)alkanoyloxy]-phenyl, 3,5- bis [(3-8C)alkanoyloxy]phenyl, 3-[(3-8C)alkanoyloxy]methyl-4-[(3-8C)alkanoyloxy]phenyl, 4-[(3-8C)alkanoyloxy]phenyl, 2-chlorophenyl or 3,5-dichloro-4-aminophenyl; R.sup.2 and R.sup.3 are independently hydrogen or (1-4C) alkyl; A.sup.1 is (1-4C) alklylene; A.sup.2 is a direct bond or (1-4C) alkylene; R.sup.4 is hydrogen, (1-6C)alkyl, phenyl-(1-4C)alkyl or halogenophenyl-(1-4 C)alkyl; and R.sup.5 is (1-6C)alkyl; or R.sup.4 and R.sup.5 together form (2-5C) alkylene; and Q is (3-12C) alkanoyl, [(3-6C)alkoxy]carbonyl, phenylacetyl, phenoxyacetyl, benzoyl or benzyloxycarbonyl, the phenyl rings of which may optionally bear a substitutent selected from halogeno, (1-4C)alkyl, (1-4C)alkoxy and trifuloromethyl; and the pharmaceutically acceptable acid-addition salts thereof; processes for their manufacture; and pharmaceutical compositions thereof.
The compounds of formula I are topical anti-inflammatory agents. A representative compound is 1-[3,4-bis (pivaloyloxy)phenyl]-2-{2-[(N-phenylacetyl-proyly)amino]-1,1-dimethyl-ethy lamino}ethanol.

REFERENCES:
patent: 3607859 (1971-09-01), Feder
patent: 3639476 (1972-02-01), Eberle et al.
patent: 3933911 (1976-01-01), Main
patent: 3944611 (1976-03-01), Smith
patent: 3957870 (1976-05-01), Main
patent: 4041075 (1977-08-01), Smith
patent: 4211878 (1980-07-01), Smith

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

1-Phenyl-2-aminoethanol derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 1-Phenyl-2-aminoethanol derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1-Phenyl-2-aminoethanol derivatives will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-592530

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.