1-phenyl-2-aminocarbonylindole compounds, preparation thereof an

Details 1-phenyl-2-aminocarbonylindole compounds, preparation thereof an 1-phenyl-2-aminocarbonylindole compounds, preparation thereof an

1987-11-20

1989-03-21

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142282, 5142352, 514323, 514419, 544 62, 544144, 546201, 548454, 548467, 548484, 548492, A61K 31405, C07D20942

Patent

active

048143456

ABSTRACT:
Novel 1-phenyl-2-aminocarbonylindole compounds are disclosed having the general formula I ##STR1## wherein R.sub.1 is an aliphatic or aromatic acyl group or an optionally substituted benzyl group; R.sub.2 is hydrogen or a lower alkyl radical; R.sub.3 is a hydrogen, a halogen, a lower alkyl radical, or a lower alkoxy radical; R.sub.4 is hydrogen, a halogen, a lower alkyl radical, or a lower alkoxy radical; R.sub.5 has the significance given R.sub.3 ; R.sub.6 has the significance given for R.sub.4, or R.sub.6 is nitro or trifluoromethyl; R.sub.7 and R.sub.8 each represent hydrogen or a lower alkyl radical, or together with a nitrogen atom form a heterocyclic group; and Z signifies an alkylene chain optionally substituted by hydroxy or acyloxy. The compounds have pharmacological, in particular antiarrhythmic, properties.

REFERENCES:
patent: 4059583 (1977-11-01), McComsey
Ariens, E. J., Drug Design, (1971: Academic Press, N.Y.), pp. 10-11.
Burger, A., Medicinal Chemistry, 3rd ed., (1970: Wiley-Interscience, N.Y.), pp. 71 and 55.
Burger, A., Medicinal Chemistry, Part I, 4th ed., (1980: Wiley-Interscience, N.Y.), p. 175.

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