1-Phenyl-1H-pyrazolo [3,4-b]pyrazine derivatives and process for

Details 1-Phenyl-1H-pyrazolo [3,4-b]pyrazine derivatives and process for 1-Phenyl-1H-pyrazolo [3,4-b]pyrazine derivatives and process for

1982-09-29

1984-07-17

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

424250, 544118, 544357, C07D48704, A61K 31495

Patent

active

044607733

ABSTRACT:
Novel 1-phenyl-1H-pyrazolo[3,4-b]pyrazine derivatives are provided which are represented by the formula: ##STR1## wherein A is (i) ##STR2## in which R.sub.1 and R.sub.2 are hydrogen or an alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl or amino group, or a divalent radical forming a nitrogen-containing saturated heterocyclic ring together with the nitrogen atom, (ii) ##STR3## wherein R.sub.3 is a phenyl group which is unsubstituted or substituted by halogen or a lower alkyl, lower alokoxy, carboxyl or nitro group, and R.sub.4 is halogen or a methyl or ethyl group, (iii)--OR.sub.5 in which R.sub.5 is a phenyl group which is unsubstituted or substituted by halogen or a hydroxyl, lower alkyl, lower alkoxy, amino or lower alkylamide group, or (iv)--OR.sub.6 is an alkyl group which is unsubstituted or substituted by halogen or a phenyl, furanyl, tetrahydrofuranyl or alkylamino group. These derivatives have antitumor or antiviral activity.

REFERENCES:
patent: 3957782 (1978-05-01), Hoehn Hans
patent: 4303658 (1981-12-01), Paris et al.
Guarreri et al., Chem. Abstract 71, 81306v.

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