1-phenoxy-3-(4-phenylpiperidino)-2-propand having both alpha- an

Details 1-phenoxy-3-(4-phenylpiperidino)-2-propand having both alpha- an 1-phenoxy-3-(4-phenylpiperidino)-2-propand having both alpha- an

1983-03-18

1987-02-10

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514212, 514227, 514233, 540524, 540578, 544121, 544360, 544372, A61K 31495, C07D40100

Patent

active

046423079

ABSTRACT:
1-phenoxy-3-(4-phenylpiperazino)-2-propanol derivatives of the formula (I): ##STR1## and pharmaceutically acceptable salts thereof wherein R.sup.1 is hydrogen, halo or lower alkyl; R.sup.2 is pyrrolidino, piperidino, morpholino or perhydroazepino unsubstituted or substituted by carbonyl at the alpha-position; R.sup.3 is hydrogen, lower alkyl or lower alkoxycarbonyl; and R.sup.4 is hydrogen, lower alkyl unsubstituted or alpha-substituted by lower alkoxy, lower alkoxy, halo or lower alkanoyl are useful for their alpha and beta-adrenergic blocking action and their hypotensive activity in humans and animals.

REFERENCES:
patent: 4413006 (1983-11-01), Kanno et al.
Franke et al, Chem. Abst. 97=216231b.
Aoyaji et al, Chem. Abst. 100=51240u.
Seidelmann, Chem. Abst. 92=215464q.
Thieme et al, Chem. Abst. 95=169204s.
Schacht et al, Chem. Abst. 83=163806v.

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