1-Phenoxy-2-hydroxy-3-tert.-butylamino propane antiarrhythmic co

Details 1-Phenoxy-2-hydroxy-3-tert.-butylamino propane antiarrhythmic co 1-Phenoxy-2-hydroxy-3-tert.-butylamino propane antiarrhythmic co

1975-04-25

1977-08-02

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

2605707, A61K 31135, C07C 9306

Patent

active

040396851

ABSTRACT:
A compound selected from the group consisting of racemates of 1-phenoxy-2-hydroxy-3-tert.-butylamino propanes of the formula ##STR1## wherein R is selected from the group consisting of alkynyloxy of 2 to 4 carbon atoms, and R.sub.1 is selected from the group consisting of hydrogen, halogen and alkoxy of 1 to 4 carbon atoms, their optically active isomers and their non-toxic, pharmaceutically acceptable acid addition salts of said racemates and said optically active isomers which compounds possess bradycardia activity and isoproterenol antagonistic activity and also antiarrhythmic activity.

REFERENCES:
patent: 3379761 (1968-04-01), Wilhelm
patent: 3483221 (1969-12-01), Wilhelm
patent: 3501769 (1970-03-01), Crowther et al.
patent: 3542874 (1970-11-01), Keizer et al.
patent: 3872147 (1975-03-01), Koppe et al.

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