1-Phenethyl-alpha-phenyl-piperidine-3-propanenitriles and their

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...

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546197, 546231, A61K 31445, C07D21134

Patent

active

044812078

ABSTRACT:
Compounds of the formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 each represent a hydrogen atom, a halogen atom, a (C.sub.1-4)alkoxy radical, a (C.sub.1-4)alkylthio radical, a halogeno(C.sub.1-4)alkyl radical, a (C.sub.1-4)alkyl radical or a cycloalkyl-alkoxy-alkoxy radical or two of the adjacent R symbols together form a methylenedioxy or ethylenedioxy radical, R.sub.6 represents a hydrogen atom, a (C.sub.1-4)alkyl radical, a (C.sub.3-6)cycloalkyl radical or a (C.sub.3-6)cycloalkyl-(C.sub.1-4)alkyl radical, and R.sub.7, R.sub.8 and R.sub.9 each represent a hydrogen atom or a methoxy radical, are new compounds possessing pharmacological properties; they are useful as calcium antagonists and as antihypertensives.

REFERENCES:
patent: 4399286 (1983-08-01), Lawson

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