1-Peptidyl derivatives of di-O-aminoglycosyl-1,3-diaminocyclitol

Details 1-Peptidyl derivatives of di-O-aminoglycosyl-1,3-diaminocyclitol 1-Peptidyl derivatives of di-O-aminoglycosyl-1,3-diaminocyclitol

1978-01-30

1979-09-25

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Reduced antigenicity, reduced ability to bind complement, or...

2601125R, 536 17R, A61K 3700, C07C10352

Patent

active

041691415

ABSTRACT:
Disclosed herein are di-O-(aminoglycosyl)-1,3-diaminocyclitol antibacterial agents having on the 1-N-position of the 1,3-diaminocyclitol moiety a dipeptidyl or a tripeptidyl substituent. The compounds are useful antibacterial agents, as are their non-toxic pharmaceutically acceptable acid addition salts. Also disclosed are methods for preparing such agents from di-O-(aminoglycosyl)-1,3-diaminocyclitol antibacterial agents which are unsubstituted at the 1-N-position.

REFERENCES:
patent: 4001208 (1977-01-01), Umezawa et al.
patent: 4009264 (1977-02-01), Mizutani
patent: 4082735 (1978-04-01), Jones et al.
patent: 4082736 (1978-04-01), Jones et al.

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