(1-Oxo-7,8-disubstituted-1,2,3,4-tetrahydro-6-naphthyloxy)- and

Details (1-Oxo-7,8-disubstituted-1,2,3,4-tetrahydro-6-naphthyloxy)- and (1-Oxo-7,8-disubstituted-1,2,3,4-tetrahydro-6-naphthyloxy)- and

1973-10-12

1977-01-18

Morganstern, Norman

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260308D, 260475SC, 260473F, 260559R, 424269, 424308, 424317, 424324, C07C 63595

Patent

active

040039277

ABSTRACT:
(1-Oxo-7,8-disubstituted-1,2,3,4-tetrahydro-6-naphthyloxy)- and (3,4-disubstituted-5-oxo-6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yloxy)ac etic acids, their carboxylate salts, and the amide and 5-tetrazole derivatives thereof are active as diuretic and saluretic agents, which also have uricosuric activity.

REFERENCES:
patent: 3369025 (1968-02-01), Bolhofer
patent: 3668241 (1972-06-01), Cragoe et al.
patent: 3704314 (1972-11-01), Cragoe et al.
patent: 3776944 (1973-12-01), Brown et al.
Topless et al., J. Pharm. Sci. 57 (5) p. 737 (1968).
Burger, "Medicinal Chemistry" 3rd Ed. (1970) 64-72.

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