1-oxo-2- (phenylsulphonylamino) pentylpiperidine derivatives, th

Details 1-oxo-2- (phenylsulphonylamino) pentylpiperidine derivatives, th 1-oxo-2- (phenylsulphonylamino) pentylpiperidine derivatives, th

1996-10-30

1998-05-19

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514351, 514357, 514459, 514461, 514667, 544242, 546300, 546302, 546335, 546334, 546290, 548187, 548202, 549476, 549491, 549495, 549 62, 549 65, 549 74, 549 75, 549 76, 564305, A61K 3144, A61K 3135, C07D23900, C07D21184, C07D30702, C07D27720, C07D31700, C07D33322

Patent

active

057536678

ABSTRACT:
The present invention provides a compound of formula (I) ##STR1## in which R.sub.1 represents a hydrogen atom or a (C.sub.1 -C.sub.4)alkyl group, R.sub.2 represents a hydrogen atom or a straight or branched (C.sub.1 -C.sub.4)alkyl group, R.sub.3 represents a straight or branched (C.sub.1 -C.sub.7)alkyl group, a group --(CH.sub.2).sub.n OCH.sub.3 (where n is 1, 2 or 3) or a group --CH.sub.2 O(C.sub.2 H.sub.4 O).sub.m CH.sub.3 (where m is 1, 2 or 3), R.sub.4 represents a hydrogen atom or a halogen atom, R.sub.5 represents a straight or branched (C.sub.1 -C.sub.4)alkyl group and A represents phenyl or heterocyclic group optionally substituted with one or more substituents independently chosen from halogen atoms and straight or branched (C.sub.1 -C.sub.4)alkyl, straight or branched (C.sub.1 -C.sub.4)alkoxy and trifluoromethyl groups, or a cyclo(C.sub.5 -C.sub.8) alkyl group, in the form of the free base or of a pharmaceutically acceptable addition salt thereof, a process for their preparation and their use in the treatment of thrombosis and thrombotic complications.

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