[1-Oxo-2-halo(or hydrogen) indanyloxy]-alkanoic acid

Details [1-Oxo-2-halo(or hydrogen) indanyloxy]-alkanoic acid [1-Oxo-2-halo(or hydrogen) indanyloxy]-alkanoic acid

1976-05-05

1978-01-24

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

260308D, 2605011, 26050116, 26050121, 260516, 260546, 260558S, 260559B, 560 10, 424308, C07C 6976

Patent

active

040705390

ABSTRACT:
[1-Oxo-2-halo(or hydrogen)indanyloxy(or thio)]-alkanoic acid products and salts, esters and amide derivatives where the indanyl ring may be further substituted with from 2 to 5 nuclear substituents. The [1-oxo-2-haloindanyloxy-(or thio)]alkanoic acids are prepared (1) via the halogenation of a [1-oxoindanyloxy(or thio)]alkanoic acid or (2) via the addition of halogen to a [1-oxoindenyloxy(or thio)]-alkanoic acid. The [1-oxoindanyloxy(or thio)]alkanoic acids are prepared (1) via cyclialkylation of a (2-alkylideneacyl)-phenoxy(or thio)alkanoic acid or (2) via etherification of a hydroxy(or mercapto)-2-alkyl-1-indanone. The [1-oxo-2-halo(or hydrogen)indanyloxy(or thio)]alkanoic acids are diuretics and saluretics. In addition, some of these compounds are also able to maintain the uric acid concentration in the body at pretreatment level or to cause a decrease in uric acid concentration.

REFERENCES:
patent: 3668241 (1972-06-01), Crayoe et al.
patent: 3984465 (1976-10-01), Crayoe et al.

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