1-Oxo-2,2-disubstituted-5-indanyloxy(or thio)alkanoic acids

Details 1-Oxo-2,2-disubstituted-5-indanyloxy(or thio)alkanoic acids 1-Oxo-2,2-disubstituted-5-indanyloxy(or thio)alkanoic acids

1973-09-21

1976-10-05

Morgenstern, Norman

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260240R, 260240D, 260240K, 260308D, 260470, 260473F, 2605011, 26050116, 26050121, 260516, 260546, 260558S, 260559B, 424269, 424308, 424315, 424318, 424324, C07C 6514, C07C 6976

Patent

active

039844650

ABSTRACT:
1-Oxo-2,2-disubstituted-5-indanyloxy(or thio)alkanoic acids and their salt, ester, anhydride, amide and 5-tetrazolyl derivatives are disclosed. The products display a dual pharmaceutical utility in that they exhibit diuretic, saluretic and uricosuric activity. The acid products are prepared by treating a 2,2-disubstituted-5-hydroxy(or mercapto)-1-indanone with an haloalkanoic acid or ester thereof and, if the ester is employed, hydrolyzing the ester.

REFERENCES:
patent: 3668241 (1972-06-01), Cragoe et al.
Topliss et al., J. Pharm. Sci., 57 (5) 1968, pp. 737-740.

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