1-Oxo-2,2-disubstituted-5-indanyloxy(or thio)alkano acids

Details 1-Oxo-2,2-disubstituted-5-indanyloxy(or thio)alkano acids 1-Oxo-2,2-disubstituted-5-indanyloxy(or thio)alkano acids

1976-07-13

1978-03-28

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

560 10, 560 53, 260308D, 260473F, 260520C, 260558S, 260559B, 424250, 424262, 424269, 424308, 424319, 424324, A61K 3119, C07C 6976, A61K 31235, A61K 31165

Patent

active

040815544

ABSTRACT:
1-Oxo-2,2-disubstituted-5-indanyloxy(or thio)alkanoic acids and their salt, ester, anhydride, amide and 5-tetrazolyl derivatives are disclosed. The products display a dual pharmaceutical utility in that they exhibit diuretic, saluretic and uricosuric activity. The acid products are prepared by treating a 2,2-disubstituted-5-hydroxy(or mercapto)-1-indanone with an haloalkanoic acid or ester thereof and, if the ester is employed, hydrolyzing the ester.

REFERENCES:
patent: 3668241 (1972-06-01), Cragoe et al.

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