1-Oxo-1,2,3,4-tetrahydro-3-isoquinoline carboxylic acid derivati

Details 1-Oxo-1,2,3,4-tetrahydro-3-isoquinoline carboxylic acid derivati 1-Oxo-1,2,3,4-tetrahydro-3-isoquinoline carboxylic acid derivati

1983-07-01

1985-08-27

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D21724

Patent

active

045379670

ABSTRACT:
The following new isocarbostyryl derivatives represented by the general formula [I]: ##STR1## wherein R.sub.1 is a hydrogen atom or a lower alkyl group, are provided, said derivatives having excellent angiotensin converting enzyme inhibitory activity with expectations therefore being as a hypotensor, and prepared by solvolysis of a compound of the following general formula [II]: ##STR2## wherein R.sub.1 is the same as defined above, R.sub.2 is an acyl group, and R.sub.3 is a hydrogen atom, an alkyl group or an aralkyl group.

REFERENCES:
patent: 3928612 (1975-12-01), Sellstedt et al.
patent: 3975535 (1976-08-01), Buckle et al.
patent: 4046889 (1977-09-01), Ondetti et al.
patent: 4118494 (1978-10-01), Kunstmann et al.
patent: 4251444 (1981-02-01), Freed
patent: 4256751 (1981-03-01), Hayashi et al.

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