1-oxaspiro[4,5] decane-7,8-diaminoarylamides

Details 1-oxaspiro[4,5] decane-7,8-diaminoarylamides 1-oxaspiro[4,5] decane-7,8-diaminoarylamides

1989-10-10

1991-05-28

Brust, Joseph P.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548407, A61K 3134, A61K 3138, A61K 3140, C07D40502

Patent

active

050195883

ABSTRACT:
Novel 1,2-cyclohexylaminoaryl amides useful as analgesic agents having very high kappa-opioid affinity and selectivity and potency and useful as analgesics, diuretics, antiinflammatory and psychotherapeutic agents are disclosed. Methods for making the compounds and pharmaceutical compositions containing them are also disclosed.

REFERENCES:
patent: 4438130 (1984-03-01), Kaplan
patent: 4463013 (1984-07-01), Collins et al.
patent: 4588591 (1986-05-01), Kaplan et al.
patent: 4598088 (1986-07-01), Szmuszkovicz et al.
patent: 4656182 (1987-04-01), Horwell
patent: 4737493 (1988-04-01), Horwell
patent: 4906655 (1990-03-01), Horwell et al.

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