1-Oxa-.beta.-lactam antibiotics

Details 1-Oxa-.beta.-lactam antibiotics 1-Oxa-.beta.-lactam antibiotics

1980-09-17

1981-11-17

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

C07D41314

Patent

active

043012825

ABSTRACT:
Bicyclic 1-oxa-.beta.-lactam diacid antibiotics represented by the formula ##STR1## wherein R is phenyl, hydroxyphenyl, acetoxyphenyl, alkylphenyl, or halophenyl, thienyl or furyl; R.degree. is H or OCH.sub.3 ; and the pharmaceutically acceptable non-toxic salts thereof are broad spectrum antibiotics useful for controlling infections in man and animals. The compounds are prepared by reacting the corresponding 3-halomethyl diester with 1-cyanomethyl-1H-tetrazole -5-thiol followed by deesterification.

REFERENCES:
patent: 4013653 (1977-03-01), Wolfe
patent: 4138486 (1979-02-01), Narisada
patent: 4226866 (1980-10-01), Christensen et al.
Williams, "Detoxication Mechanisms" 2nd Ed. pp. 396-402, John Wiley & Sons, Inc, New York, (1959).

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