Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1978-10-26
1981-01-13
Jiles, Henry R.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
26032616, 2603403, 26034863, 546 16, 546 19, 546186, 546242, 546268, A61K 31445, C07D49810
Patent
active
042449618
ABSTRACT:
Compounds of the formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are the same or different and are hydrogen, C.sub.1 to C.sub.6 alkyl, C.sub.6 to C.sub.14 carbocyclic aryl or aralkyl of 1 to 6 carbon atoms in the alkyl moiety and 6 to 12 carbon atoms in the carbocyclic aryl moiety and R.sup.4 is selected from the group having the formula ##STR2## where R is C.sub.1 to C.sub.8 alkyl, C.sub.1 to C.sub.8 alkoxy, halo, cyano, AlkNHC(O)-- or AlkC(O)NH-- and R' is Alk NHC(O) or Alk C(O)NH where Alk is C.sub.1 to C.sub.6 alkyl or the group 2-(endobicyclo[3.1.0]hexyl)ethyl. Methods for preparing the compounds are disclosed. The compounds are useful for the treatment of hypertension and cardiac disorders.
REFERENCES:
patent: 3399192 (1968-08-01), Regnier et al.
patent: 3577425 (1971-05-01), Nakanishi et al.
patent: 3594386 (1971-07-01), Regnier et al.
Chemical Abstracts, 71:91359d (1969) [Regnier, G. et al., Chim. Ther., 1969, 4(3), 185-194].
Chemical Abstracts, 78:71968t (1973) [Maillard, J. et al., Chim. Ther., 1972, 7(6), 458-466].
Chemical Abstracts, 81:105368b (1974) [Maillard, J. et al., Eur. J. Med. Chem.-Chim. Ther., 1974, 9(2), 128-132].
Kluge Arthur F.
Unger Stefan H.
Blaufarb Gerard A.
Jiles Henry R.
Moran Tom M.
Schwartz Richard A.
Syntex (U.S.A.) Inc.
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