1(Or 3)-perfluoroalkyl-3,4-dihydro-2(1H)-isoquinolinecarbonitril

Details 1(Or 3)-perfluoroalkyl-3,4-dihydro-2(1H)-isoquinolinecarbonitril 1(Or 3)-perfluoroalkyl-3,4-dihydro-2(1H)-isoquinolinecarbonitril

1975-06-19

1976-05-11

Rollins, Alton D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D21700

Patent

active

039563332

ABSTRACT:
(1-R- or 3-trifluoromethyl)-3,4-dihydro-2(1H)-isoquinolinecarboxamidoximes where R is pentafluoroethyl or heptafluoropropyl, having antithrombotic and antibacterial activities, are prepared by reacting the corresponding (1-R- or 3-trifluoromethyl)-3,4-dihydro-2(1H)-isoquinolinecarbonitriles which are prepared from the corresponding (1-R- or 3-trifluoromethyl)-3,4-dihydroisoquinolines via the (1-R- or 3-trifluoromethyl)-1,2,3,4-tetrahydroisoquinolines. Said tetrahydroisoquinoline where R is pentafluoroethyl also has antibacterial activity.

REFERENCES:
patent: 3505336 (1970-04-01), Bailey
patent: 3637709 (1972-01-01), Houlihan et al.
patent: 3769291 (1973-10-01), Parker et al.

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