1-(.omega.-HALOALKYL)-ISATOIC ANHYDRIDES

Details 1-(.omega.-HALOALKYL)-ISATOIC ANHYDRIDES 1-(.omega.-HALOALKYL)-ISATOIC ANHYDRIDES

1975-08-06

1977-03-22

Daus, Donald G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602564F, 424251, C07D26526

Patent

active

040136469

ABSTRACT:
CNS depressants of the formulae IA and IB: ##STR1## in which n and p are each 0 or 1, Z.sup.- is an anion and R.sub.1, R'.sub.1, R.sub.2, R'.sub.2, R.sub.3 and R.sub.4 are optional substituents. Compounds IB may be prepared by reducing compounds IA which may be made by reacting a N-(.omega.-haloalkyl) isatoic anhydride with a cyclic pseudothiourea such as a 2-organomercapto-4,5-dihydroimidazole. Compounds IB may be also prepared by cyclizing a 1-(.omega.-haloalkyl)-2,3-dihydro-imidazo[2,1-b]quinazolin-1H-5-one. The compounds are anti-inflammatory, analgesic and immunosuppressant agents.

REFERENCES:
patent: 3383415 (1968-05-01), Carabateas
patent: 3725321 (1973-04-01), Wirth et al.

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