1-Nitro-2-(2-alkynylamino)-2-[(2-pyridylmethylthio)-ethylamino]e

Details 1-Nitro-2-(2-alkynylamino)-2-[(2-pyridylmethylthio)-ethylamino]e 1-Nitro-2-(2-alkynylamino)-2-[(2-pyridylmethylthio)-ethylamino]e

1980-03-10

1981-08-04

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546286, 546306, 546300, 424263, C07D21338

Patent

active

042823633

ABSTRACT:
Compounds of the formula ##STR1## wherein R.sup.1 is a straight or branched chain alkynyl group containing from 3 to 9 carbon atoms, inclusive; R.sup.2 is hydrogen, hydroxy, cyano, (lower)alkyl, (lower)alkoxy, halogen or amino; n is 2 or 3; X is NR.sup.3 or CHR.sup.3 ; R.sup.3 is cyano, nitro, SO.sub.2 Ar; or SO.sub.2 (lower)alkyl; R.sup.12 is hydrogen or (CH.sub.2).sub.p NR.sup.13 R.sup.14 ; p is an integer of from 1 to 4, inclusive; R.sup.13 and R.sup.14 each are independently hydrogen or (lower)alkyl; and Ar is phenyl or phenyl containing 1 or 2 substituents independently selected from halogen and (lower)alkyl; and nontoxic, pharmaceutically acceptable salts thereof, are potent anti-ulcer agents.

REFERENCES:
patent: 3953460 (1976-04-01), Durant et al.
patent: 4060621 (1977-11-01), Durant et al.
patent: 4098898 (1978-07-01), Durant et al.
patent: 4112234 (1978-09-01), Crenshaw et al.
patent: 4200760 (1980-04-01), Algieri et al.
patent: 4203909 (1980-05-01), Algieri et al.
Ganellin et al., Federation Proceedings, vol. 35, pp. 1924-1930, (1976).
Drugs of the Future, vol. I, No. I, (1976).

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