Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1988-11-18
1991-01-15
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
549220, C07C 906, C07C 928, A01N 5700, A61K 31665
Patent
active
049854143
ABSTRACT:
New 1-naphtholphthalein monophosphates of the formula ##STR1## wherein each of R.sup.1 and R.sup.2 is hydrogen or halogen, and each of M.sup.1 and M.sup.2 is a proton or an alkali metal, alkaline earth metal, ammonium, dicyclohexylammonium, tetraalkylammonium or alkanolammonium cation, and the tautomeric transformation products thereof, are useful as substrates for detection and photometric determination of alkaline phosphotase.
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patent: 3823071 (1974-07-01), Roy
patent: 3931228 (1976-01-01), Borror
patent: 3975405 (1976-08-01), Hamill
patent: 4032545 (1977-06-01), Borror
patent: 4035391 (1977-07-01), Borror
Roy, "Rapid Method for Determining Alkaline Phosphotase Activity . . . ", Clin. Chem. 16, 431-6 (1970).
Morin, "Ammonium Thymolphthalein Monophosphate as a New Substitute . . . ", Clin. Chem. 19, 1135-8 (1973).
Abstract: Tapaneic Published Pat. Appl. No. 58-158199 (1983).
Guethlein Werner
Merdes Hartmut
Boehringer Mannheim GmbH
Covington Raymond
Raymond Richard L.
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