1,N.sup.6 -etheno-5'-adenosine carboxylates for increasing coron

Details 1,N.sup.6 -etheno-5'-adenosine carboxylates for increasing coron 1,N.sup.6 -etheno-5'-adenosine carboxylates for increasing coron

1974-05-21

1976-07-27

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

A61V 3170

Patent

active

039718492

ABSTRACT:
Esters of 1,N.sup.6 -etheno-5'-adenosine carboxylic acid represented by the formula ##SPC1##
Wherein R.sub.1 is loweralkyl, loweralkenyl, loweralkynyl or cycloalkyl; and R.sub.2 and R.sub.3 each are hydrogen or acyl, or R.sub.2 and R.sub. 3 taken together form an isopropylidene or benzylidene moiety; and the pharmaceutically acceptable acid addition salts thereof.
The compounds wherein R.sub.2 and R.sub.3 are hydrogen are useful in treating cardiovascular disorders and are particularly useful as anti-anginal and anti-hypertensive agents. Compounds wherein R.sub.2 and R.sub.3 are acyl or when taken together form an isopropylidene or benzylidene moiety are intermediates useful in the preparation of the final products. (R.sub.2 and R.sub.3 = hydrogen). The final products are also useful as intermediates for preparing pharmaceutically active compounds, and, more specifically, for preparing the corresponding 1,N.sup.6 -etheno-5'-adenosine carboxamides.

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