1,N.sup.6 -etheno-5'-adenosine carboxamides for increasing coron

Details 1,N.sup.6 -etheno-5'-adenosine carboxamides for increasing coron 1,N.sup.6 -etheno-5'-adenosine carboxamides for increasing coron

1974-05-21

1976-01-06

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

A61K 3170

Patent

active

039314014

ABSTRACT:
Amides of 1,N.sup.6 -Etheno-5'-adensine carboxylic acid represented by the formula ##SPC1##
Wherein R.sub.1 and R.sub.2 each are hydrogen, loweralkyl, loweralkenyl, loweralkynyl or cycloalkyl, and R.sub.3 and R.sub.4 each are hydrogen, acyl, or R.sub.3 and R.sub.4 taken together form an isopropylidene or benzylidene moiety; and the pharmaceutically acceptable acid addition salts thereof.
The compounds wherein R.sub.3 and R.sub.4 are hydrogen are useful in treating cardiovascular disorders and are particularly useful as anti-anginal and anti-hypertensive agents. Compounds wherein R.sub.3 and R.sub.4 are acyl or when taken together form an isopropylidene or benzylidene moiety are intermediates useful in the preparation of the final products. (R.sub.3 and R.sub.4 = hydrogen).

REFERENCES:
patent: 3551409 (1970-12-01), Kampe et al.
patent: 3697504 (1972-10-01), Schmidt

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